Paracetamol 500mg

Category:- Antibiotics-arv | Type:- Tablet

Composition :
Each uncoated tablet contains:
Paracetamol  BP 500 mg.
 

Pharmacodynamic Properties: 
Pharmacotherapeutic group: Analgesic and anitipyretic
ATC code: N02BE01
 

Pharmacodynamics / pharmacokinetics
Mechanisms of Action/Effect
Analgesic –Paracetamol may act predominantly by inhibiting prostaglandin synthesis in the central nervous system (CNS) and to a lesser extent, through a peripheral action by blocking pain-impulse generation.
The peripheral action may also be due to inhibition of prostaglandin synthesis or to inhibition of the synthesis or actions of other substances that sensitise pain receptors to mechanical or chemical stimulation. Antipyretic – paracetamol probably produces antipyresis by acting centrally on the hypothalamic heat-regulation centre to produce peripheral vasodilation resulting in increased blood flow through the skin, sweating and heat loss. The central action probably involves inhibition of prostaglandin synthesis in the hypothalamus.
 

Pharmacokinetic Properties:
Absorption: Paracetamol pharmacokinetics are linear after a single administration of up to 2 g and after repeated administration during 24 hours.
The maximum plasma concentration (Cmax) of paracetamol observed at the end of 15-minutes intravenous infusion of Paracetamol 150 mg/mL, solution for infusion is about 15 μg/mL. Distribution:  The volume of distribution of paracetamol is approximately 1 L/kg. Paracetamol is not extensively bound to plasma proteins. Metabolism: Paracetamol is metabolised mainly in the liver following two major hepatic pathways: glucuronic acid conjugation and sulphuric acid conjugation. A small fraction (less than 4%) is metabolised by cytochrome P450 to a reactive intermediate (N-acetyl benzoquinone imine) which, under normal conditions of use, is rapidly detoxified by reduced glutathione and eliminated in the urine after conjugation with cysteine and mercapturic acid. However, during massive poisoning, the quantity of this toxic metabolite is increased. Elimination: The metabolites of paracetamol are mainly excreted in the urine. 90% of the dose administered is excreted in 24 hours, mainly as glucuronide (60-80%) and sulphate (20-30%) conjugates. Less than 5% is eliminated unchanged. Plasma half-life is 2.7 hours and total body clearance is 18 L/h.
 

Indications 
CETAMOL-500 Tablets is indicated for the Management of mild to moderate pain. 
Management of moderate to severe pain with adjunctive opioid analgesics. 
Reduction of fever.