Piperacillin 4gm Tazobactam 500mg

Category:- Antibiotics-arv | Type:- Tablet

PHARMACOLOGICALCLASSIFICATION:

Pharmacotherapeutic group: Antibacterials for systemic use, Combinations of penicillins, including beta-lactamase inhibitors. ATC code: J01C R05

Mechanism of action:

Piperacillin, a broad spectrum, semisynthetic penicillin exerts bactericidal activity by inhibition of both septum and cell wall synthesis.

Tazobactam, a beta-lactam structurally related to penicillins, is an inhibitor of many beta-lactamases, which commonly cause resistance to penicillins and cephalosporins but it does not inhibit AmpC enzymes or metallo beta-lactamases..

Tazobactum extends the antibiotic spectrum of piperacillin to include many beta-lactamase-producing bacteria that have acquired resistance to piperacillin alone.

Indications:

Piperacillin/Tazobactam is indicated for the treatment of the following infections in adults and children over 2 years of age:

Adults and Adolescents

- Severe pneumonia including hospital-acquired and ventilator-associated pneumonia

- Complicated urinary tract infections (including pyelonephritis)

- Complicated intra-abdominal infections

- Complicated skin and soft tissue infections (including diabetic foot infections)

Treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above.

Piperacillin/Tazobactam may be used in the management of neutropenic patients with fever suspected to be due to a bacterial infection.

Dosage and directions foruse:

Dosage

The dose and frequency of Piperacillin/Tazobactam depends on the severity and localisation of the infection and expected pathogens. Adult and adolescent patients Infections

The usual dose is 4 g piperacillin / 0.5 g tazobactam given every eight hours.

For nosocomial pneumonia and bacterial infections in neutropenic patients, the recommended dose is 4 g piperacillin / 0.5 g tazobactam administered every six hours. This regimen may also be applicable to treat patients with other indicated infections when particularly severe.

Directions for use

Piperacillin/Tazobactam 2 g / 0.25 g is administered by intravenous infusion (over 30 minutes).

Piperacillin/Tazobactam 4 g / 0.5 g is administered by intravenous infusion (over 30 minutes).