Amlodipine 5mg Atorvastatin 10mg

Category:- Cardiology | Type:- Tablet

Each uncoated tablet contains :

Amlodipine Besilate BP

Equivalent to Amlodipine 5 mg

Atorvastatin Calcium

Equivalent to Atorvastatin 10 mg

DESCRIPTION

This tablet combines the long-acting calcium channel blocker amlodipine besilate with the synthetic lipid-lowering agent atorvastatin calcium.

MECHANISM OF ACTION

It is a combination of two drugs, a dihydropyridine calcium antagonist (calcium-channel blocker) amlodipine (antihypertensive/antianginal agent) and an HMG-CoA reductase inhibitor atorvastatin (cholesterol lowering agent). Amlodipine inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Atorvastatin is a selective, competitive inhibitor of HMG-CoA reductase (statin), the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol.

INDICATIONS AND USAGE

It is indicated in patients for whom treatment with both amlodipine and atorvastatin is appropriate.

Amlodipine

1. Hypertension

2. Coronary Artery Disease (CAD)

l Chronic Stable Angina

l Vasospastic Angina (Prinzmetal's or Variant Angina)

l Angiographically Documented