Meropenem 500mg /1gm

Category:- Gastrointestinal | Type:- Injection

Compositions: 
Each vial contains: 
Meropenem Trihydrate USP 
Eq. to Anhydrous Meropenem 
(Also contains Sodium Carbonate) 
(Sodium 90.2 mg) 

Pharmacotherapeutical group and anatomic-therapeutic-chemical classification code (ATC): 
Carbapanem antibiotic, J01 DH02 
 

Pharmacological Properties: 
Meropenem is a carbapenem antibiotic for parenteral use, that is relatively stable to human dehydropeptidase-1 (DHP-1) and therefore does not require the addition of an inhibitor of DHP-1. Meropenem exerts its bactericidal action by interfering with vital bacterial cell wall synthesis. The ease with which it penetrates bacterial cell walls, its high level of stability to all serine beta­lactamases and its marked affinity for the Penicillin Binding Proteins (PBPs) explain the potent bactericidal action of meropenem against a broad spectrum of aerobic and anaerobic bacteria. 
Minimum bactericidal concentrations (MBC) are commonly the same as the minimum inhibitory concentrations (MIC). For76% of the bacteria tested, the MBC: MIC ratios were 2 or less. 
 

Indications: 
Copenem is indicated for treatment, in adults and children, of the following infections caused by single or multiple bacteria sensitive to meropenem. 

Pneumonias and nosocomial pneumonias Urinary tract infections 
Intra-abdominal infections 
Gynaecological infections, such as endometritis. Skin and skin structure infections 
Meningitis 
Septicaemia