CLENBOLIC - Clenbuterol Hydrochloride 25mcg/40mcg/60mcg

Category:- Hormones | Type:- Tablet

Composition

Each Tablet Contains: Clenbuterol Hydrochloride BP40 mcg

Clinical Pharmacology

Clenbuterol exerts a pronounced action on the metabolism; with both anabolic and anti-catabolic effects. Clenbuterol has been demonstrated to increase the rate of protein synthesis in muscle tissue and to increase protein to fat ratio. Clenbuterol is a beta-2 adrenergic agonist relaxing airway muscle tissue and proving bronchodialation. Clenbuterol increases aerobic capacity, pulse perspiration and blood pressure; increases basal metabolic rate and temperature. Clenbuterol has an oral bioavailability of 89 to 98 % with a half- life of 36 to 48 hours after oral use.

Indication

To increase the rate of protein synthesis in muscle tissue and to increase protein to fat ratio in human.

Contraindication

Children or geriatric patients Individuals who have been diagnosed of cardio-vascular problems should not take Clenbuterol. Women who are pregnant or may become pregnant Concomitantly with other CNS stimulants, adrenergic, or hypertensive agents In patients with hypersensitivity to Clenbuterol or other ingredients In patients with a history of GI bleeding, ulceration of the stomach, or gastritis

Precautions

Clenbuterol can produce significant cardiovascular effects in some patients as evidenced by elevated pulse rate, blood pressure changes and or ECG changes. The patients who use Clenbuterol should be monitored for changes in heart rate, arterial blood pressure and or oxygen saturation of arterial blood. Urticaria and tachycardia may be observed during the few first days of treatment; if this occurs; discontinue and consult physician immediately. Not for use by nursing mothers due to unknown effect from excreted milk.

Use in pregnancy

Although animal experiments showed no teratogenic effects. st Clenbuterol should not be used during the 1 trimester of pregnancy because of its labour inhibiting action and it should not be taken shortly before childbirth.

Drug Interaction

Clenbuterol may enhance the action and side effects of other beta –adrenergic mimetics, theophylline and anti- cholinergic. Beta blockers may inhibit the action of Clenbuterol; thus a risk of bronchospasm exists with concomitant uses. Clenbuterol may alter the action of hypoglycemic agents, insulin sensitizers, insulin and insulin secretagogues. Adjust of dosage may be required. Monitor for loss of glycaemic control. There is an increased risk of arrhythmia with concomitant administration of halogenated carbohydrates for nacrosis; e.g. during surgery. Concomitant use with diuretics and digitalis glycosides requires periodic monitoring of serum electrolytes.Concomitant use with other CNS stimulants should be avoided given the cumulative stimulatory effects and increased risk of adverse events. Concomitant use with MAO- inhibitors and tri- cyclic antidepressant may produce cardiac dysrhythmias.

Adverse Reactions

CNS: Nervousness, tremor, ataxia, dizziness, restlessness, agitation, anxiety, insomnia and headache

Cardiovascular

Palpitations, tachycardia, hypertension, angina, ventricular extra systole, myocardial infarction

Metabolic

Increases basal temperature/ pyrexia, diaphoresis and electrolyte disturbances: elevated serum CK; thrombocytopenia, hypoglycemia, rarely thyrotoxicosis. Respiratory: paradoxical bronchial spasm.

Others

Urticaria, facial, oedema, cramping, relaxation of uterine lining, gastric irritation, nausea, vomiting, dry mouth, constipations, cough and local irritation, difficulty in urinations & urinary retention and hypersensitivity reactions.

Dosages

20-40 mcg twice daily

Overdosage

Overdose Clenbuterol Hydrochloride may be characterised by: tremor of the fingers, significant sweating, headache and tachycardia. Extreme and severe overdose cases have presented with collapse, seizures, coma and death. In case of overdose Clenbuterol use should be discontinued. Stomach lavage with activated charcoal, forced diuresis and symptomatic therapy should be performed

Presentation

Clenbolic is supplied 5x10 tablets blister packed in carton along with package insert.

Storage Instruction

Clenbolic should be stored at controlled room temperature below 30ºC and protect from light

Manufactured by: COOPER PHARMALIMITED