OXANBOLIC - Oxandrolone USP 10mg/50mg

Category:- Hormones | Type:- Tablet

COMPOSITION

Each Tablet Contains: Oxandrolone USP 10 mg

INDICATIONS

Certain cases of disseminated breast cancer in women. Osteoporosis due to androgen deficiency in hypogonadal males.

CONTRA-INDICATIONS

Not intended for use in children. Known or suspected prostatic carcinoma and mammary carcinoma in the male. Not intended for use in female patients other than those with disseminated breast cancer. Contraindicated in nephrosis or the nephrotic phase of nephritis, cardiac and renal failure, hypercalcaemia, oedema, jaundice, liver disease with impaired bilirubin excretion, testicular and hepatic carcinoma.

DOSAGE AND DIRECTIONS FOR USE

Oxanbolic should be taken orally per day in divided doses. Adult dose: 5-10 mg every day.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS

Virilisation which appears in sensitive women as hoarseness, acne, hirsutism, and increased libido; in prepubertal boys as an increased frequency of erections and phallic enlargement, and in girls as an increase of pubic hair and clitoral hypertrophy. Hoarseness may be the first symptom of vocal change which may end in a long-lasting, sometimes irreversible deepening of the voice.

OTHER ADVERSE REACTIONS MAY INCLUDE

Oligospermia and decreased ejaculatory volume; Suppression of ovarian activity, atrophy of the breasts and endometrial tissue. Amenorrhoea and inhibition of spermatogenesis. Water and salt retention. Premature epiphyseal closure. If signs of virilisation develop, treatment should be discontinued. Increase in nitrogen retention and skeletal weight; Oedema; Increased vascularity of the skin; Increased growth of the bone; Elderly males may become over-stimulated.

PATIENTS WITH THE FOLLOWING CONDITIONS SHOULD BE MONITORED

Latent or overt cardiac failure, renal dysfunction, hypertension, epilepsy or migraine (or a history of these conditions), since anabolic steroids may induce salt and fluid retention; diabetes, since anabolic steroids may improve the glucose tolerance and decrease the need for insulin or other antidiabetic drugs; incomplete statural growth, since anabolic steroids in high dosages may accelerate epiphyseal closure; skeletal metastases, since anabolic steroids may induce hypercalcaemia and hypercalciuria in these patients.

INTERACTIONS

Oral hypoglycaemic agents: may inhibit the metabolism of oral hypoglycaemic agents which may require adjustments of dosage. Anti coagulants: Patients on anticoagulants should be carefully monitored during anabolic steroid therapy as anabolic steroids may increase sensitivity to oral anticoagulants. Patients should be monitored regularly during anabolic steroid therapy, particularly during initiation and termination of therapy.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT

See "Side-effects and special precautions". Treatment is symptomatic and supportive.

Over Dosage

Signs and symptoms of over dosage are those associated with the known effects of the drug. See adverse reactions section. Treatment is symptomatic and supportive. Evacuate stomach contents by emesis and, if indicated, lavage, taking care to prevent aspiration. Monitoring of liver function is advised. Precautions: Elevated liver enzymes and in extreme cases hepatic liver dysfunction may occur, 17 alpha alkylated androgens may cause cholestatic hepatitis and jaundice, particularly with larger dosages or prolonged treatment. Liver function should be monitored for changes including serum bilrubin, aspartete aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatise (AP). Edema may be increased in patients on concurrent adrenal cortical steroid or ACTH therapy. Anabolic steroid hormones may increase low density lipoproteins (LDL) and decrease high density lipoproteins (HDL). Lipids levels generally return to normal upon discontinuation of treatment.

PRESENTATION

Oxanbolic 5x10 tablets blister packed in carton along with package insert.

STORAGE INSTRUCTIONS

Oxanbolic should be stored at controlled room temperatures below 30°C and protected from light. If it has expired or is damaged, return it to your pharmacist for disposal.

Keep Out Of Reach Of Children.

Manufactured by: COOPER PHARMALIMITED